Blogging around the world

Watching the Masters at Work

admin — Sun, 26 Feb 2012 16:58:43 +0000

If only your eyes could see what mine have seen. Trying to find an ophthalmic contract researcher, is, for me, a very rigorous process. I’m looking for the most cutting edge technology, for the best in their field at testing the preclinical efficacy and pharmacokinetics of polymer based drug depots for the retina, and unique innovations in ophthalmic test beds. My clients, and their customers, demand the best in vitro and in vivo testing of retinopathy treatments, and demand capabilities down to the 100 nm range for advanced polymer capabilities, nanoparticle synthesis and formulation, and treatments that continue to deliver for longer than just a few days or weeks – we demand long term delivery curves, out to six months. But when all of the searching, all of the research, all of the interviewing and touring of facilities is complete, there is really only one choice for the kind of preclinical efficacy and the kind of final results I need: EyeCRO. Their mastery of laser technology alone is something completely unique in my experience. Their innovative application of FDA approved polymers for injection site depots allows drug diffusion in the eye over the course of several days, and their combination of study design, veterinary, ocular surgery, formulation, cell biology and molecular biology skill sets allows them to pursue the entire process from compound formulation to testing to delivery. Just their capacity to produce nanoparticles in the 100-300 nm range incorporating hydrophobic drugs is beyond impressive, it’s amazing. So, there really is no choice at all. It’s EyeCRO, all the way.

A Close Eye on Contract Research

admin — Mon, 20 Feb 2012 16:28:11 +0000

A few hours spent touring EyeCRO’s state-of-the-art facility is a real education. This place shows you, with every turn of the corner and every open door, what the future looks like. For both in vivo and in vitro retinal disease models and retinopathy preclinical efficacy trials, EyeCRO’s use of the strictest pharmacokinetics for dependable outcomes, plus the precision of laser technology is the only way to go if you’re looking for a lab that can model, test and study treatments for vascular permeability of the retina, and degeneration of the retina and ocular angiogenesis. These are the top experts in the field for formulation of depot forming injectables, eye drops, fluorescent micro and nanoparticles, microparticles, and PLGA nanoparticles. Cutting edge FDA approved polymers enable vitreous injection take lab results beyond preclinical application to the eyes, and the healthy sight, of your patients. Creation of formulations which remain in the injection site, and allow the FDA approved polymer to diffuse away and leave a depot of the drug behind is some of the most incredible biotechnology I’ve ever seen. The depot can then diffuse to the retina for sustained delivery of several days. This level of technology places EyeCRO beyond formulation of lab compounds, in the real world of treatment of patients for retinal and ocular disease and degeneration. EyeCRO is changing the world of ophthalmic research, one patient at a time.

Ophthalmic Research With Vision

admin — Sat, 18 Feb 2012 16:40:39 +0000

EyeCRO is a globally recognized team of research scientists focused on ophthalmic disease. Founded in 2005 from a contract to study the effects of one of the world’s largest pharmaceutical company’s drugs in an animal model, the company has outgrown its single-client beginnings to become one of the most respected organizations in their field, specializing in retinopathy, preclinical efficacy trials, pharmacokinetics research, and advanced laser technology, all the while maintaining their association with the University of Oklahoma Health Sciences Center which allows them to keep costs down. EyeCRO not only excels at formulation of eye drops, depot forming injectables, fluorescent micro and nanoparticles, microparticles, PLGA nanoparticles, as well as depot forming injectables, but in preclinical efficacy trials to prove out those formulations for the eye as a whole, and for the retina especially, with reliable results and innovative techniques such as FDA approved polymers in vitreous depot delivery which allow the depot of the drug to diffuse into the eye over the course of several days. With their associated backgrounds in formulation, study design, ocular surgery, veterinary, cell biology and molecular biology, these dedicated experts bring a singular and unique blend of expertise to the study of advanced therapies and compound testing and formulation. For everything from the lab to the delivery to the clear and healthy vision of the patients who will thank you for their improved health, EyeCRO has all bases covered, with dedicated experts, one-of-a-kind resources and facilities, and a personal care for the quality of their work.

Contract Ophthalmic Research That is a Sight to Behold

admin — Thu, 09 Feb 2012 16:46:24 +0000

Be honest: anyone who’s been in this industry any length of time knows that the wrong contract researcher can ruin a business plan. Finding the right team to test the preclinical efficacy and pharmacokinetics of polymer based drug depots for the retina is no laughing matter, it is serious business, and making the wrong choice can be disastrous. It’s difficult enough to find a facility with the capability of working down to the 100 nm range in nanoparticle production. You just don’t have that many choices. And my needs are particular. I need delivery curves out to six months. I need a team with the knowledge base that allows the use of FDA approved polymers for vitreous depots. I need a CRO that can handle retinopathy preclinical efficacy trials as well as formulation. And I demand the kind of results the arise out of technologies from laser to fluorescent micro- and nanoparticles with sizes of 100 to 300 nm, 5um and 30um. Of course, in my case, we got lucky. We not only found a CRO with all of these capabilities and more, but with the added bonus of being associated with the University of Oklahoma Health Sciences Center, which adds to my appreciation of the quality of science being done, but also helped to keep our costs in check. Of course, finding that they are outstanding client servants and knowledgeable designers of trial and formulation programs when we started working with them was just the bonus that let me know I’d made the right choice. And the results were phenomenal. Who knew?

Contract Research With an Eye on the Future

admin — Fri, 03 Feb 2012 16:17:17 +0000

EyeCRO is composed of the most complete group of specialists in retinopathy, pharmacokinetics, veterinary medicine, and formulation of unique delivery systems for vitreous delivery and retina treatment, and this diverse and talented team brings singular expertise to preclinical efficacy trials for advanced ophthalmic formulation and delivery. They use all levels of technology and experimentation: laser tech, utilizing a combination of formulation proficiency and historical awareness of vehicle suitability, and a lead candidate selection process and a formulation custom designed and precisely calibrated for your preclinical needs.

The team at EyeCRO knows this process better than anyone else in the business, and their unmatched expertise in physiochemical drug characteristics, the rigorous application of preformulation screens prior to formal formulation development experiments, and years of experience in efficacy testing make them the only logical choice for development and production of nanoparticles in the 100-300 nm range, applied to proprietary technology for incorporating hydrophobic drugs to tailor drug loading from 10% to 40%, which can, amazingly, create in vitro release profiles as much as six months long. Their client-oriented

consultation for appropriate study design allows them to meet your objectives and goals, and they have a consistent and reliable history of on-time and under-budget project and distinguish themselves from large CRO’s with incredible customer service and attention to detail. The people you want developing advanced Pharmacokinetics for your needs are the dedicated, caring, and trusted experts that make up the EyeCRO staff.

How do you do it?

admin — Mon, 21 Nov 2011 00:55:02 +0000

I’ve been getting that question a lot lately, and why not? Fitness has always been kind of a drag for me, and I looked like it. Flabby and tired all of the time, moody, pale. But lately, I’ve been looking a lot better, and feeling a lot better, and making different choices about my health. People around Boca Raton are noticing, and not just the guys. My girlfriends are always after me, what’s my secret? Did I hire a personal trainer to come scream at me every morning and force-feed me chemical shakes instead of meals? Did I join one of those gyms where they take you in back and give you all kinds of injections? Was it (shudder) lipo? No. It’s Boca Raton Fitness, and a different way of looking at my health. When a friend tipped me off, and said the words “boot camp” I hesitated, I’ve seen the movies, I know what boot camp is all about. But this was different – at BR Fitness, they have a small group of people who are fun and into what they’re doing being guided by two personal trainers, so, it’s almost like being in a class, working on your projects together. The workouts are different every day, so I don’t get bored, and because the styles vary, I don’t hit that wall that makes me want to quit and go home. And the guest chefs teaching healthy cooking, the dieticians meal planning based on my likes, and the grocery store tours have changed my whole lifestyle. So I feel good, and I look good. That’s how I do it.

A Company to Look Out For

admin — Sun, 20 Nov 2011 01:04:24 +0000

Watching EyeCRO! When you look for the best in contract research, you want to see the highest of high tech capabilities. Testing the preclinical efficacy and pharmacokinetics of polymer based drug depots for the retina is not for the faint of heart, and it isn’t your grandma’s ophthalmic test beds. Only the most capable, only the most advanced team of multifield experts is going to cut it. In vitro and in vivo testing of retinopathy treatments is serious science, and I want to see capabilities down to the 100 nm range for nanoparticle synthesis and formulation, I want to see advanced polymer capabilities, and treatments that continue to deliver way past a window of a few days or weeks, I want to see long term delivery curves, out to six months. Picking a CRO is serious business, and choosing a team for development of treatments for vitreous and retinal issues requires vision at a level of granularity that is rare, if not unheard of. You want to see that your team has not only the ability to formulate workable treatments, but to formulate the proper preclinical trials to validate those treatments, and then the historical awareness of vehicle suitability, to ensure a lead candidate selection process and a formulation suitable for your needs. When you’re looking for serious expertise in incorporated hydrophobic drugs with the ability to tailor the drug loading from 10% to 40% w/w, you actually don’t have to look very far. When I want to see excellence in ophthalmics, I look at EyeCRO.

Fitness as a Lifestyle

admin — Sun, 20 Nov 2011 00:53:32 +0000

No one tells Kal Gunay he has to do it like everyone else. He doesn’t, and he wouldn’t. At Boca Raton Fitness, he is re-writing the book on healthy living, exercise, and nutrition. This is not like any of the gyms I’ve ever gone to for a few weeks before giving up out of some nameless kind of frustration that things just aren’t right. But that’s because warehouse gyms and “fitness centers” that are packed full of people socializing and crowding regular people out aren’t about healthy living and thinking, they’re about selling an image. And my image of myself isn’t of a person who wants to do dead lifts of Olympic-class weights, or of a person who goes to the gym to meet someone to date. I wasn’t sure what my image was, but Boca Raton Fitness helped me find it for myself: I’m a person who likes being part of a group “boot camp” with a personal trainer or two helping us through individual and varied workouts. I like being educated by guest chefs in a real kitchen on how to cook healthy meals for myself that taste good and are the kind of food that I like to eat. I like going through the grocery store with a nutritionist and learning how to see through the promises on the labels to real nutrition and good food. I like feeling good, and I like taking care of my health. I like Boca Raton Fitness, and I’m glad Kal doesn’t let anyone tell him how to run a good gym. He knows.

EyeCRO Shows 20/20 Vision

admin — Sat, 19 Nov 2011 01:06:35 +0000

Let’s face it, choosing the wrong contract researcher is short-sighted. Testing the preclinical efficacy and pharmacokinetics of polymer based drug depots for the retina takes serious scientific chops, and a level of expertise that is hard to find. How many researchers and formulation experts can you name that work down to the 100 nm range in nanoparticle production? There just plain aren’t that many out there. And when you narrow that search down to those that have an ophthalmic specialty, the field of view becomes vanishingly small. And in that very small, very hard-to-find group of top-notch specialists, you have to make a choice. You have to look closely at your options. Things to look for? How about treatments that continue to deliver way past a window of a few days or weeks, long term delivery curves, out to six months? How about singular expertise in the use of FDA approved polymers for vitreous depots? And I think that microparticles designed to stay in the vitreous and release the drug plus nanoparticles designed to enter cells directly and release the drug intracellularly are key indicators that you’re dealing with the cutting edge of the leading experts in their field. Basically, there is only one contract researcher out there that has the grasp of technologies from laser to fluorescent micro- and nanoparticles with sizes of 100 to 300 nm, 5um and 30um, has the relationships with university labs to keep costs down, and the history of coming in on time and under budget. EyeCRO is clearly in focus, and the search is over.

Keeping an Eye Out for the Best Contract Research

admin — Sat, 19 Nov 2011 01:04:11 +0000

EyeCRO provides consultation to design an appropriate study for your goals and objectives, has a long history of completing projects on time and under budget, and sets itself apart from the large CRO’s through customer service and attention to detail. EyeCRO has fielded the most balanced team of specialists in veterinary medicine, retinopathy, pharmacokinetics, and formulation of unique delivery systems for vitreous delivery and retina treatment, and they bring this expertise to preclinical efficacy trials for advanced ophthalmic formulation and delivery. The use of every level of technology and study from laser tech to utilizing a combination of our formulation proficiency and historical awareness of vehicle suitability, they ensure a lead candidate selection process and a formulation suitable for your preclinical needs. No one knows this process better than EyeCRO, and the subtleties of development needs are not lost on them – far from it. The deep knowledge of physiochemical drug characteristics, the rigorous application preformulation screens prior to formal formulation development experiments, and the vast expertise in efficacy testing make them, far and away, the foremost experts in their field. The development and production of nanoparticles in the 100-300 nm range applied to proprietary technology for incorporating hydrophobic drugs allows these scientists to tailor drug loading from 10% to 40%, and create in vitro release profiles that extend for as long as six months! And this is just scratching the surface of their capabilities. This is tech that has to be seen to be believed.